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there are two types of industrialized production of mannitol: one type is natural mannitol which is extracted from kelp. the other type is synthetic mannitol which is produced by using sucrose and glucose as raw materials. mannitol is a polyols with 6 hydroxyl, the appearance is white needle crystal. it is odorless with sweet taste, easy soluble in water.
typical applications:mannitol is of stable properties, and it does not need insulin in its physiological metabolism. with its own unique physiological properties, mannitol is widely used in medicine, food and other industrial fields. for example:
in medicine -- mannitol is a good diuretic, it can be used to reduce intracranial pressure, intraocular pressure and to be as renal medicine, dehydrating agent, substitutes of sugar, etc. it can also be used as excipient of tablet and diluent agent of solid or liquid. as a hypotensor with high permeability, mannitol injection is commonly used in clinical rescue, particularly in brain disorders. it is of the characteristics of reducing pressure fast and accurate curative effect, which are what the drug of reducing intracranial pressure requires. as excipients of tablets, mannitol is non-hygroscopic, and of drying quickly, good chemical stability. it is also refreshing and easy to form particles. it can be used in most tablets such as anticancer drugs, antibiotics, antihistamines and vitamin, etc. in addition, it can be used in chewing tablets such as sobering up medicine and mouth refreshing agent, etc.
in food industries – the absorbency of mannitol in sugar and sugar alcohols is in minimum level. it is of refreshing sweet taste and used in the anti-adherence of food such as malt sugar, gum and rice cake etc, as well as used as adhesion-proof powders of general cake. it can also be used as low calorific value and low sugar content sweeteners like food and body-building food for diabetes patients.
in other industries -- mannitol can be used in plastics industry to produce rosin ester, synthetic glycerol resin, explosives and detonators ( nitromannite ) etc. it can also be applied to determinate boron in chemical analysis and as bacterial culture agent in biological test, etc.
cp2010, while based on the requirements of customers, products in line with bp or usp standard are also available.
specification | cp2010 | bp2012 | usp32 |
appearance |
white crystalline powder,odorless,slightly sweet |
white crystalline powder or flowable granule |
white crystalline powder |
content,% | 98.0~102.0 | 98.0~102.0 | 96.0~101.5 |
melting point,℃ | 166~170 | 165~170 | 164~169 |
specific optical rotation,° | +137~+145 | +23~+25 | +137~+145 |
identification1、2 | qualified |
qualified |
infrared absorptiong method(197k) |
clarity and color | qualified | / | qualified |
clarity and color | clear and colorless or less than 1 turbidity standard solution | clear and colorless | / |
related substances | qualified | qualified | / |
reducing sugar | qualified | ≤0.2% | qualified |
chloride,% | ≤0.003 | / | ≤0.007 |
sulphate,% | ≤0.01 | / | ≤0.01 |
oxalate,% | ≥0.02 | / | / |
loss on drying,% | ≤0.5 | ≤0.5 | ≤0.3 |
residue,% | ≤0.1 | / | / |
heavy metals,% | 不得过百万分之十 | / | / |
arsenic salt,% | ≤0.0002 | / | ≤1ppm |
nickel,ppm | / | ≤1 | / |
lead,ppm | / | ≤0.5 | / |
bacterial endotoxin,iu/g | / | qualified | / |
packing:
25 kg / poly woven bags or cardboard drums